The Germline DNA project will draw on the combined patient resources of the Sydney Children’s Hospitals Network to conduct next-generation sequencing of germline DNA from both retrospectively- and prospectively-identified cancer patients, and in the latter case, from their immediate family members. We anticipate that this approach will identify known cancer-predisposing mutations showing expected and unexpected associations with cancer diagnoses within the cohort, as well as new genetic variants that could be associated with cancer risk. This is a unique project in Australia that will represent the first analysis of tumour predisposition in child cancer patients using whole genome sequencing. The project will also help us to better understand the unique experiences of families who face not only the challenges of navigating a cancer diagnosis in a child, but also need to cope with the additional complexities of potential genetic implications for the whole family.
Started: 1 July 2017
Ending: 31 December 2018
Professor Jennifer Byrne
Principal Investigator:
